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Academic Papers

Abington Reproductive Medicine physicians have been recognized locally by their peers as "Top Docs" and are known internationally as leading researchers, lecturers and educators. They are involved in clinical and scientific research and are contributors to or have been published in various reproductive medicine literature.

To read recent academic papers written or co-written by our physicians, please click on the links below.

Journal of Experimental & Clinical Assisted Reproduction
Published February 10, 2010. Stephen G. Somkuti, M.D., Ph.D.; Larry I. Barmat, M.D.; Jay S. Schinfeld, M.D.; Scott E. Smith, Ph.D., HCLD; and Maria Wikarczuk, B.A. Embryologist.
Objective: To determine if a less expensive, easier, and faster to perform HBA test is clinically equal to the more complicated, technically challenging and expensive SPA test as a reliable indicator of sperm fertilizing capacity. (pdf attachment)

“Rare, isolated fallopian tube torsion”
Roberto P. Harris, MD; Larry Barmat, MD

“Da Vinci-assisted abdominal cerclage"
Objective: To report the first placement of an abdominal cervicoisthmic cerclage using the da Vinci robot.
A video of this procedure was presented by Larry Barmat, M.D., at the 2007 national meeting of the American Society for Reproductive Medicine in Washington, D.C.

“Patient experience with follitropin alfa prefilled pen versus previously used injectable gonadotropins for ovulation induction in oligoanovulatory women”
Objective: To evaluated patient satisfaction with the follitropin alfa prefilled pen (Gonal-f RFF Pen).

“Relationship between maternal age and aneuploidy in in vitro fertilization pregnancy loss”
Objective: To determine the fetal loss rate after documented fetal cardiac activity (seven-week sonogram) and to evaluate the chromosomal makeup of these losses in IVF pregnancies.

“Mouse ascites Golgi mucin expression abnormalities in natural cycle endometrial biopsies predict subsequent in vitro fertilization-embryo transfer (IVF-ET) failure in patients with previous IVF-ET failures.”
Objective: To determine whether endometrial expression of mouse ascites Golgi mucin in a natural, unmedicated cycle predicts subsequent IVF-ET outcome among women with prior IVF-ET failure and poor pre-embryo quality.

“Growth factor expression by human oviduct and buffalo rat liver coculture cells”
Objective: To characterize growth factor gene expression by passaged coculture cell lines demonstrated to enhance in vitro pre-embryo growth.

“Oocyte donation: does a previous attempt affect a subsequent attempt?”
Objective: To analyze the effect of a previous donor oocyte cycle on the outcome of subsequent attempts.

“Accessory uterine appendage may be a new mullerian malformation”
Objective: To describe a case of an accessory uterine structure.

“Human preembryo development on autologous endometrial coculture versus conventional medium”
Objective: To evaluate the effect of autologous endometrial coculture versus conventional medium on preembryo development.

“A randomized prospective trial comparing gonadotropin-releasing hormone (GnRH) antagonist/recombinant follicle-stimulating hormone (rFSH) versus GnRH-agonist/rFSH in women pretreated with oral contraceptives before in vitro fertilization”
Objective: To compare the effects of oral contraceptive (OC) pill pretreatment in recombinant FSH/GnRH-antagonist  versus recombinant FSH/GnRH-agonist stimulation in in vitro fertilization (IVF) patients, and to evaluate optimization of retrieval day.

“MAG mucin expression abnormalities in natural cycle biopsies predict subsequent IVF failure”
Objective: We have previously shown that MAG mucin expression abnormalities in endometrial biopsies are correlated with reproductive outcome in patients with longstanding infertility and in donor/recipient IVF cycles. In this study we attempted to determine if the expression of MAG in a natural cycle prior to a medicated IVF cycle predicted IVF success.

“The linear increase in pregnancy loss after clinical pregnancy in IVF is related to chromosomal abnormalities”
Objective: To determine the fetal loss rate after a documented fetal heart (FH) and to evaluate the chromosomal makeup of these losses.

“Single cell RT-PCR detection of IGF-1 and IGF-1 receptor mRNA expression in preimplantation mouse embryo: Correlation with in vitro development”
Objective: Recent studies have demonstrated the importance of insulin like growth factors (IGF's) in murine preimplantation development. Supplementation of culture media with IGF-1 increases the rate of blastocyst formation and the inner cell mass cell number. We studied IGF-s gene expression in a single blastomere of an early murine embryo and correlated it with subsequent embryo development in culture.

“The embryo toxicity of hydrosalpinx fluid is only apparent at high concentrations: an in vitro model that simulates in vivo events”
Objective: To simulate the in vivo model in studying the effect of hydrosalpinx fluid on embryonic development.

“Are cytokines and growth factors responsible for the detrimental effects of hydrosalpingeal fluid on pregnancy rates after in vitro fertilization-embryo transfer?”
Objective: To characterize the secretion of cytokines and growth factors in hydrosalpingeal fluid.

“Importance of the biopsy date in autologous endometrial cocultures for patients with multiple implantation failures”
Objective: To analyze the effectiveness of autologous endometrial coculture by the cycle day of the endometrial biopsy.

“Seasonality of spontaneous and IVF pregnancy rates and temperature/humidity effect on IVF”
Objective: A seasonal effect on spontaneous pregnancy rates has been observed in the general population. The purpose of this study was to evaluate the fluctuation of pregnancy rates over time in the normal population and in an in vitro fertilization patient population. A secondary goal was to determine if IVF laboratory temperature and humidity were associated with IVF clinical pregnancy rates.

“Prospective randomized trial of autologous endometrial coculture versus traditional IVF”
Objective: One factor that may contribute to the poor success rates in IVF may be the suboptimal culture conditions in which fertilization and early embryonic growth occur. This may result in embryos with compromised growth rates and reduced viability. Therefore, in an effort to more closely mimic the in vivo preimplantation environment the culture of embryos on a layer of cells has been developed (coculture). In April 2002, the FDA recommended that nonhuman coculture cell lines not be used in human IVF due to the concern of xenologous viral transmission. Therefore, in an attempt to alleviate these concerns and to improve IVF success rates, our objective was to determine if embryo development and clinical outcome is improved by autologous endometrial coculture (AECC).

“Effect of supplementation of leukemia inhibitory factor and epidermal growth factor on murine embryonic development in vitro, implantation and outcome of offspring”
Objective: To evaluate the supplementation of leukemia inhibitory factor (LIF) on epidermal growth factor (EGF) in a single culture system (IVF50) and a sequential culture system (IVF50-S2) to determine whether they had any additional benefit on embryo development and implantation.

“Testicular sperm from nonobstructed azoospermic males does not appear to alter preembryo morphology or IVF pregnancy outcome”
Objective: To determine if microsurgical fertilization using sperm obtained from testicular biopsy affects in vitro fertilization/embryo transfer (IVF/ED) preembryo quality and pregnancy outcome.

“Glandular developmental arrest (GDA): a unifying model of reproductive endometrial pathology”
Objective: We evaluated the possibility that endometrial dating using histologic criteria alone may miss defects in the biochemical differentiation of the endometrial glands that could be critical for optimal endometrial receptivity.

"Secondary amenorrhea attributed to occlusion of microperforate transverse vaginal septum"
Objective: To present a case of secondary amenorrhea after occlusion of microperforate transverse vaginal septum.

"Case of sisters with complete androgen insensitivity syndrome and discordant Mullerian remnants"
Objective: Presentation of complete androgen insensitivity in two members of the same family with differing residual Mullerian tissue.

"Venous Thrombosis and Congenital Absence of Inferior Vena Cava in a Patient with Menorrhagia and Pelvic Pain"

"Postablation Tubal Sterilization Syndrome with Hematometra After Thermal Balloon Ablation"