Intracytoplasmic Sperm Injection (ICSI)
ICSI has proven beneficial in cases of male factor infertility where sperm counts are very low or fertilization was unsuccessful with prior IVF attempts.
A micromanipulation technique, ICSI involves gently placing a single sperm directly into the egg. While there appears to be no increase in congenital abnormalities in the offspring with this procedure, unexplained or genetic factors in the semen cannot always be overcome.
PICSI is a newer assisted productive technique offered at Abington Reproductive Medicine that supplements IVF/ICSI success rates.*
The embryologists use a PICSI dish, which is coated with drops of hyaluronan, a compound matrix naturally surrounding the oocyte. In vivo, sperm naturally bind to hyaluronan. Research has demonstrated sperm that bind to hyaluronan demonstrate enhanced levels of normal morphology, motility and developmental maturity. When the embryologist places sperm onto the PICSI dish, the mature sperm will become immobilized by anchoring themselves to the hyaluronan and showing tails with hyperactivation. Sperm showing this type of activation will be chosen for ICSI.
The resulting zygotes (fertilized eggs) and embryos will be evaluated using routine procedures. No other step in the patients IVF cycle will be changed from the usual procedures.
* A recent study indicates that PICSI can increase pregnancy rates up to 15%